CT of the Airways

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Federal Government. Read our disclaimer for details. Last Update Posted : July 4, Study Description. Procedures: At Visit 1, after obtaining the written informed consent of the patient, medical history, smoking status and patient's treatment will be collected. They will be asked to discontinue bronchodilator therapies as follows, such that pulmonary function tests PFT and CT scan will be initially evaluated in a medication wash-out period at Visit 2: Short acting a2 agonists and anticholinergics: 8 wash-out Long acting a2 agonists: 12h wash-out Long acting anticholinergics: 48h wash-out Theophylline preparations: 48h wash-out Antileucotrienes: 48h wash-out At visit 2, PFT will be performed, including vital capacity VC , forced vital capacity FVC , functional residual capacity FRC , total lung capacity TLC , residual volume RV , forced expiratory volume in one second FEV1 , diffusion lung capacity for carbon monoxide DLCO , and alveolar volume VA measurements either in absolute values and percentage of predicted values.

A first CT scan will be performed using the following technique: Supine CT scan after full inspiration. Airway index: from B60f reconstructions 1mm-thick every 0. FDA Resources. Supine CT scan after full inspiration. Outcome Measures.

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Eligibility Criteria. Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.


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Please refer to this study by its ClinicalTrials. Layout table for location information Belgium C. U Saint-Pierre Brussels, Belgium, More Information. Computed tomographic measurements of airway dimensions and emphysema in smokers. Correlation with lung function. Airflow limitation and airway dimensions in chronic obstructive pulmonary disease. Epub Mar Airway wall thickening and emphysema show independent familial aggregation in chronic obstructive pulmonary disease. Epub Jun Inspiratory capacity and decrease in lung hyperinflation with albuterol in COPD.

Pellegrino R, Brusasco V. On the causes of lung hyperinflation during bronchoconstriction. Eur Respir J. Failure of body plethysmography in bronchial asthma.

Assessment of Small Airways with Computed Tomography: Mosaic Attenuation or Lung Density?

Airway wall thickness in cigarette smokers: quantitative thin-section CT assessment. Epub Apr Chronic obstructive pulmonary disease: thin-section CT measurement of airway wall thickness and lung attenuation. Epub May Pubmed citation 2. Imaging the airways. Hemoptysis, bronchiectasis, and small airways disease. Chest Med. Pubmed citation 3. Hansell DM.

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Article - MDCT of the central airways: Anatomy and pathology

Semin Respir Crit Care Med. Imaging of small airways disease. J Thorac Imaging. High-resolution CT of peripheral airways diseases. North Am. Pubmed citation 7.

Radiographics abstract - Pubmed citation 8. Tree-in-bud pattern at thin-section CT of the lungs: radiologic-pathologic overview. Radiographics full text - doi Free text at pubmed - Pubmed citation Respir Med.

Introduction

Small airways diseases, excluding asthma and COPD: an overview. European Respiratory Review. Promoted articles advertising. Edit article Share article View revision history Report problem with Article.

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