Federal Government. Read our disclaimer for details. Last Update Posted : July 4, Study Description. Procedures: At Visit 1, after obtaining the written informed consent of the patient, medical history, smoking status and patient's treatment will be collected. They will be asked to discontinue bronchodilator therapies as follows, such that pulmonary function tests PFT and CT scan will be initially evaluated in a medication wash-out period at Visit 2: Short acting a2 agonists and anticholinergics: 8 wash-out Long acting a2 agonists: 12h wash-out Long acting anticholinergics: 48h wash-out Theophylline preparations: 48h wash-out Antileucotrienes: 48h wash-out At visit 2, PFT will be performed, including vital capacity VC , forced vital capacity FVC , functional residual capacity FRC , total lung capacity TLC , residual volume RV , forced expiratory volume in one second FEV1 , diffusion lung capacity for carbon monoxide DLCO , and alveolar volume VA measurements either in absolute values and percentage of predicted values.
A first CT scan will be performed using the following technique: Supine CT scan after full inspiration. Airway index: from B60f reconstructions 1mm-thick every 0. FDA Resources. Supine CT scan after full inspiration. Outcome Measures.
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Eligibility Criteria. Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
- Chest Imaging - Lung and Airway Disorders - MSD Manual Consumer Version.
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